Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N ε-trimethyllysine† †Electronic supplementary information (ESI) available: Synthesis procedures, assay conditions, NMR assignments and spectra, and MS analyses. See DOI: 10.1039/c6cc08381a Click here for additional data file.
نویسندگان
چکیده
Nε-Trimethyllysine hydroxylase (TMLH) catalyses the first step in mammalian biosynthesis of carnitine, which plays a crucial role in fatty acid metabolism. The stereochemistry of the 3-hydroxy-Nε-trimethyllysine product of TMLH has not been defined. We report enzymatic and asymmetric synthetic studies, which define the product of TMLH catalysis as (2S,3S)-3-hydroxy-Nε-trimethyllysine.
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عنوان ژورنال:
دوره 53 شماره
صفحات -
تاریخ انتشار 2016